Lymphocyte subset abnormalities in early diffuse cutaneous systemic sclerosis

Treatment outcome in early diffuse cutaneous systemic sclerosis: the European Scleroderma Observational Study (ESOS)

OBJECTIVES The rarity of early diffuse cutaneous systemic sclerosis (dcSSc) makes randomised controlled trials very difficult. We aimed to use an observational approach to compare effectiveness of currently used treatment approaches. METHODS This was a prospective, observational cohort study of early dcSSc (within three years of onset of skin thickening). Clinicians selected one of four proto...

Augmented ICOS expression in patients with early diffuse cutaneous systemic sclerosis.

OBJECTIVE Inducible costimulator (ICOS), expressed on activated T cells, and its ligand, ICOS ligand (ICOSL), expressed on antigen-presenting cells, have been considered a single receptor-ligand pair. Here we investigated the expression of ICOS and ICOSL in patients with SSc. METHODS ICOS expression on peripheral blood T cells, and ICOSL expression on B cells and macrophages was determined by...

Thymoglobulin and cyclophosphamide as treatment for diffuse cutaneous systemic sclerosis.

Disease progression in systemic sclerosis-overlap syndrome is significantly different from limited and diffuse cutaneous systemic sclerosis

BACKGROUND Systemic sclerosis (SSc)-overlap syndromes are a very heterogeneous and remarkable subgroup of SSc-patients, who present at least two connective tissue diseases (CTD) at the same time, usually with a specific autoantibody status. OBJECTIVES To determine whether patients, classified as overlap syndromes, show a disease course different from patients with limited SSc (lcSSc) or diffu...

EXTENDED REPORT Disease progression in systemic sclerosis-overlap syndrome is significantly different from limited and diffuse cutaneous systemic sclerosis

Disease progression in systemic sclerosis-overlap syndrome is significantly different from limited and diffuse cutaneous systemic sclerosis Pia Moinzadeh, Elisabeth Aberer, Keihan Ahmadi-Simab, Norbert Blank, Joerg H W Distler, Gerhard Fierlbeck, Ekkehard Genth, Claudia Guenther, Ruediger Hein, Joerg Henes, Lena Herich, Ilka Herrgott, Ina Koetter, Alexander Kreuter, Thomas Krieg, Kathrin Kuhr, ...